A tractor-trailer that lost its brakes on I-84 eastbound Saturday afternoon caused a chain reaction crash that ultimately involved five vehicles and caused several minor injuries. State police said the tractor-trailer, driven by Mark Drake of Lynne, Pa., rear-ended a box truck and pushed it into three cars before the box truck overturned on the highway. The crash, which occurred about 3:15 p.m., shut down the highway for about three hours, police said.